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Glutathione (GSH) is the most important and powerful natural antioxidant. GSH is found in almost every cell of the body. Unlike other antioxidants, GSH is endogenous because our own natural production of glutathione is native to who we are as humans. It is absolutely vital for cell protection and longevity as well as for proper cell function and is, therefore, most critical for establishing and maintaining good health. Glutathione levels are highest in cells of our bodily organs which are most susceptible to toxicity, such as the liver, lungs, kidneys,heart, eyes, brain and skin. Thus, GSH protects against oxidative stress and nitrogen free radicals when produced in excess, and any free radicals created by exposure to radiation from ultraviolet light, x-rays, gamma-rays and cosmic-rays.
Glutathione not only neutralizes health degenerating free radicals and reactive oxygen compounds, but it also maintains exogenous antioxidants such as vitamins C and E in their reduced (active) forms. Through direct conjugation, glutathione detoxifies a great many environmental carcinogens and toxic xenobiotic (foreign) substances. GSH also protects against toxic/carcinogenic pollutants like cigarette smoke, vehicular exhaust fumes, and smoke-stack emissions.
Glutathione is essential for the proper and optimum functioning of the another endogenous antioxidant enzyme called glutathione peroxidase. Our cell membranes are made up of polyunsaturated lipids or fats and are susceptible to damage by the reactive oxygen species (ROS), especially the peroxide radicals. This damage can gravely affect the cell from getting proper nutrients into it or waste material out and if not functioning properly will lead to cellular death. The enzyme, glutathione peroxidase, detoxifies lipid peroxides (reactive by-product from oxidation of lipids by free radicals) and glutathione is a needed co-factor for this enzyme.
Glutathione is needed for the growth, reproduction and differentiation of lymphocytes and is essential for a full functioning immune system. Glutathione also plays an active role in a whole host of metabolic and biochemical reactions, such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis, amino acid transport and enzyme activation. Thus, glutathione plays a fundamental role in maintenance of optimal health. We cannot live without it.